analysis of the il-10, il-12, and tnf-α gene polymorphisms in patients with vesicoureteral reflux among the southeast iranian population
نویسندگان
چکیده
conclusions the results demonstrated significant associations between the il-10 (ag-1089, il-10ca) and il-12 (aa) gene polymorphisms and a highly increased risk of vur. background vesicoureteral reflux (vur) is a common childhood disorder that is characterized by the abnormal movement of urine from the bladder into the ureters or kidneys. objectives the aim of this study was to determine whether the genetic polymorphisms of the il-10, il-12, and tnf-α genes are involved in the development of vur. patients and methods the tetra amplification mutation refractory system-polymerase chain reaction (tetra-arms pcr) was applied to analyze the four polymorphic sites of the il-10ag-1082, il-10ca597, il-12ca1188, and tnf308ga genes in 124 vur children and 110 healthy controls. results a significant, highly increased risk of vur disease was found for the ca, aa, and combined genotypes of il-10ca597 (or = 5.2, 95% cl: 1.80 - 18.25; p = 0.0006, or = 9.1, 95% cl: 1.11 - 122.75; p = 0.02, or = 5.3, 95% cl: 1.82 - 18.61; p = 0.00052, respectively); the ag, gg, and ag + gg genotypes of il-10ag-1082 (or = 12.8, 95% cl; 2.9 - 113.9; p = 0.00003, or = 12.62, 95% cl: 2.93 - 114.53; p = 0.00003, respectively); and the aa genotype of il-12 (aa, or = 0.19, 95% cl: 0.5 - 0.55; p = 0.0006). the frequency of the c allele in both il-10ca and il-12ca was greater in patients with vur than in the healthy controls. no association was found between tnf308ga and the risk of vur.
منابع مشابه
Analysis of the IL-10, IL-12, and TNF-α Gene Polymorphisms in Patients With Vesicoureteral Reflux Among the Southeast Iranian Population
BACKGROUND Vesicoureteral reflux (VUR) is a common childhood disorder that is characterized by the abnormal movement of urine from the bladder into the ureters or kidneys. OBJECTIVES The aim of this study was to determine whether the genetic polymorphisms of the IL-10, IL-12, and TNF-α genes are involved in the development of VUR. PATIENTS AND METHODS The tetra amplification mutation refrac...
متن کاملIL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage
Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women. Method: Po...
متن کاملTNF-α, TNF-β, IL-6, and IL-10 Polymorphisms in Patients with Lung Cancer
Apart from cigarette smoking, genetic factors seem to be of importance in the development of lung cancer. The present case-control study investigated frequencies of five inflammatory response gene polymorphisms (TNF-alpha-308, TNF-beta-Intron1-252, IL-6-174, IL-10-819 and IL-10-1082) in patients with lung cancer and controls. The study population consisted of 117 patients with lung cancer (77 p...
متن کاملThe frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcer and chronic gastritis
ABSTRACT Introduction: Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The a...
متن کاملThe Association of Gastritis and Peptic Ulcer With Polymorphisms in the Inflammatory-related Genes IL-4 and IL-10 in Iranian Population
Background and Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients. Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. Inflammatory responses of gastric mucosa are associated with helicobac...
متن کاملSerum TNF-α, IL-10 and IL-2 in Schizophrenic Patients Before and After Treatment with Risperidone and Clozapine
Background: Schizophrenia is a disorder of the executive function of both sensory and central nervous system. Recent studies suggest that immune mechanisms play a role in the pathophysiology of this disease. The variations in cytokine concentrations have been associated with psychopathology and treatment of schizophrenia. Objective: To investigate the changes in serum concentrations of TNF- α, ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
nephro-urology monthlyجلد ۸، شماره ۲، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023